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APGEApogee Therapeutics, Inc.
$133.50$8.3B
Overview & Verdict
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APGE logoApogee Therapeutics, Inc.(APGE)Earnings, Financials & Key Ratios

APGE•NASDAQ
$133.50
Price updated Jul 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryImmunology and Inflammation Therapies
AboutApogee Therapeutics, Inc., through its subsidiary, operates as a biotechnology company that develops biologics for the treatment of atopic dermatitis (AD), chronic obstructive pulmonary disease (COPD), and related inflammatory and immunology indications. The company primarily develops APG777, a subcutaneous (SQ) extended half-life monoclonal antibody (mAb) for AD; and APG808, an SQ extended half-life mAb for COPD. Its earlier-stage programs include APG990, an SQ extended half-life mAb for the treatment of AD; and APG222, an extended half-life SQ antibodies for AD. The company was founded in 2022 and is based in Waltham, Massachusetts.Show more
  • Revenue$0
  • EBITDA-$284M-31.1%
  • Net Income-$256M-40.5%
  • EPS (Diluted)-4.22-27.9%
  • ROE-31.57%+5.0%

APGE Price & Volume

Apogee Therapeutics, Inc. (APGE) stock price & volume — 10-year historical chart

Loading chart...

Escalating Clinical Costs Drive Persistent Operational Deficits

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical trial execution dependency

Key Thesis Takeaways

  • Apogee Therapeutics operates as a pre-revenue clinical-stage biotechnology firm, where the primary value driver remains the successful advancement of its pipeline through capital-intensive development phases.
  • The company's reliance on external equity financing to sustain operations is evidenced by a deepening retained earnings deficit of $635.9 million as of 2026Q1.
  • Investors should monitor the sustainability of this model, as the current trajectory of rising R&D expenditures and stock-based compensation may necessitate further dilutive capital raises to maintain clinical momentum.

Verdict Logic

the company's reliance on external funding to cover an accelerating quarterly free cash flow burn of $55.6 million presents significant long-term dilution risks for shareholders.

APGE Growth Metrics

Apogee Therapeutics, Inc. (APGE) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-33.7%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-19.28%

Return on Capital

10 Years-32.84%
5 Years-32.84%
3 Years-36.57%
Last Year-34.94%

APGE Recent Earnings

Apogee Therapeutics, Inc. (APGE) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)
Q2 2026Latest
May 11, 2026
Metric
Actual
Est
EPS
$1.06+0.9%
$1.07
Rev
—
—
Q2 2026
Mar 2, 2026
Metric
Actual
Est
EPS
$1.03+1.9%
$1.05
Rev
—
—
Q4 2025
Nov 10, 2025
Metric
Actual
Est
EPS
$1.11+0.9%
$1.12
Rev
—
—
Q3 2025
Aug 11, 2025
Metric
Actual
Est
EPS
$1.13-9.7%
$1.03
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 11, 2026
$1.06vs $1.07+0.9%
—
Q2 2026Mar 2, 2026
$1.03vs $1.05+1.9%
—
Q4 2025Nov 10, 2025
$1.11vs $1.12+0.9%
—
Q3 2025Aug 11, 2025
$1.13vs $1.03-9.7%
—
Based on last 12 quarters of dataView full earnings history →

Latest APGE News

Recent stock market news and headlines for Apogee Therapeutics, Inc. (APGE)

GuruFocus·Jun 25, 2026
Are TECH, APGE, BOLD, REFI Obtaining Fair Deals for their Shareholders?

Are TECH, APGE, BOLD, REFI Obtaining Fair Deals for their Shareholders? PR Newswire NEW YORK, June 25, 2026

ETF Trends·Jun 25, 2026
Biotech ETF Index Surges 10% After Rebalance

After a sweeping semi-annual rebalance, the biotech index underlying the ALPS Medical Breakthroughs ETF (SBIO) gained over 10% in just six trading days beginning June 18. Key Takeaways: SBIO's underlying index gained 10.01% in six trading days following its June 18 semi-annual rebalance.

Fool - Investing News·Jun 25, 2026
Is AbbVie a Buy After Its Purchase of Apogee?

The pharmaceutical company gains a prospective blockbuster with the deal, but is it worth $10.9 billion?

Peers Comparison

Key metrics vs top competitors for Apogee Therapeutics, Inc. (APGE)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
APGE logoAPGEApogee Therapeutics, Inc.Current
$133.50$8.26B-31.64——-31.57%—
REGN logoREGNRegeneron Pharmaceuticals, Inc.
$649.81$67.52B15.670.99%29.65%14.32%—
ACLX logoACLXArcellx, Inc.
$115.07$6.73B-28.27-79.35%-1027.25%-55.42%—
RXRX logoRXRXRecursion Pharmaceuticals, Inc.
$3.96$1.77B-2.7526.92%-844.46%-54.32%—
ARQT logoARQTArcutis Biotherapeutics, Inc.
$26.07$3.26B-200.5491.34%-0.57%-1.41%—
DAWN logoDAWNDay One Biopharmaceuticals, Inc.
$21.53$2.22B-20.7020.6%-67.85%-23.43%—

Compare APGE vs Peers

Apogee Therapeutics, Inc. (APGE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs REGN

Most directly comparable listed peer for APGE.

Scale Benchmark

vs LLY

Larger-name benchmark to compare APGE against a more recognizable public peer.

Peer Set

Compare Top 5

vs REGN, ACLX, RXRX, ARQT

APGE SEC Filings & Documents

Apogee Therapeutics, Inc. (APGE) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 11, 2026·SEC

Material company update

Apr 24, 2026·SEC

Material company update

Mar 25, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 2, 2026·SEC

FY 2025

Mar 3, 2025·SEC

FY 2024

Mar 5, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 11, 2026·SEC

FY 2025

Nov 10, 2025·SEC

FY 2025

Aug 11, 2025·SEC

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APGE Frequently Asked Questions

Apogee Therapeutics, Inc. (APGE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is APGE profitable?

Apogee Therapeutics, Inc. (APGE) reported a net loss of $274.6M for fiscal year 2025.

Dividend & Returns
What is APGE's return on equity?

Apogee Therapeutics, Inc. (APGE) has a return on equity (ROE) of -31.6%. Negative ROE indicates the company is unprofitable.

What is Apogee Therapeutics, Inc.'s free cash flow?

Apogee Therapeutics, Inc. (APGE) had negative free cash flow of $235.4M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in APGE back in 2022?

Total return calculator · dividends reinvested · 4+ years of data

See returns →